Worked example · Pericyte loss / APOE4
Corrections are events. Propagation is automatic.
A finding lands in 2016. New evidence raises its confidence. In 2020, a correction narrows its scope to APOE4 carriers. Three downstream objects are notified within hours.
F-204 · Finding v1 / 3
Pericyte loss precedes cognitive decline in early Alzheimer's.
Confidence 0.81
Event log · F-204 Signed · Provenance verified
2016-04-12 Finding Initial deposit · Halliday et al. postmortem evidence in human sporadic AD.
2019-01-14 Evidence Nation et al. longitudinal MRI confirms BBB breakdown precedes cognitive decline. Confidence ↑ 0.81 → 0.84.
2020-05-29 Correction Montagne et al. shows BBB breakdown concentrated in APOE4 carriers. Scope narrowed; confidence on broader claim ↓ 0.84 → 0.62.
pending Propagation 3 downstream objects notified: Phase II inclusion criteria · Biotech target hypothesis · Review article headline claim.
Step 1 / 3