Use of Model-Based Meta-Analysis to Inform the Design of Early Clinical Trials of Anti-Amyloid Beta Therapies in Alzheimer's Disease. — To inform an efficient development of new investigational anti-amyloid beta (anti-Aβ) monoclonal antibodies (mAbs), a modeling-and-simulation-based strategy was proposed. A general...

Evidence span

Use of Model-Based Meta-Analysis to Inform the Design of Early Clinical Trials of Anti-Amyloid Beta Therapies in Alzheimer's Disease. — To inform an efficient development of new investigational anti-amyloid beta (anti-Aβ) monoclonal antibodies (mAbs), a modeling-and-simulation-based strategy was proposed. A general...

From Bachhav SS et al. 2025, CPT: pharmacometrics & systems pharmacology

Method & conditions

Evidence type

meta_analysis

Method

manual state transition; placebo-controlled clinical trial where source reports control arm

Species

Homo sapiens

Conditions

Humans; Alzheimer Disease; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Models, Biological — CPT: pharmacometrics & systems pharmacology 2025

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required