The reduction of brain amyloid-beta by anti-TfR/BACE1 antibodies in human TfR knock-in mice is dependent on the antibody's affinity for the transferrin receptor.

Evidence span

The reduction of brain amyloid-beta by anti-TfR/BACE1 antibodies in human TfR knock-in mice is dependent on the antibody's affinity for the transferrin receptor.

From Yu YJ et al. 2014, Sci Transl Med

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

source-reported model organism

Conditions

varying TfR affinity of bispecific antibodies

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required