The Brain Shuttle version of an anti-Aβ antibody, utilizing a monovalent binding mode to the transferrin receptor (TfR), increases β-Amyloid target engagement in an Alzheimer's disease mouse model by 55-fold compared to the parent antibody.

Evidence span

The Brain Shuttle version of an anti-Aβ antibody, utilizing a monovalent binding mode to the transferrin receptor (TfR), increases β-Amyloid target engagement in an Alzheimer's disease mouse model by 55-fold compared to the parent antibody.

From Niewoehner J et al. 2014, Neuron

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

source-reported model organism

Conditions

Monovalent Brain Shuttle module engineered into an anti-Aβ antibody.

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required