Reducing the affinity of an antibody for the transferrin receptor (TfR) enhances its receptor-mediated transcytosis across the blood-brain barrier (BBB) into the mouse brain.

Evidence span

Reducing the affinity of an antibody for the transferrin receptor (TfR) enhances its receptor-mediated transcytosis across the blood-brain barrier (BBB) into the mouse brain.

From Yu YJ et al. 2011, Sci Transl Med

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

source-reported model organism

Conditions

anti-TfR antibody variants with varying affinities administered systemically

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required