Reducing anti-TfR antibody affinity for transferrin receptor enhances receptor-mediated transcytosis and brain uptake; bispecific anti-TfR/BACE1 antibody lowers brain Aβ in mice after single systemic dose. Mechanistic foundation of the Brain Shuttle delivery class.

Evidence span

Reducing anti-TfR antibody affinity for transferrin receptor enhances receptor-mediated transcytosis and brain uptake; bispecific anti-TfR/BACE1 antibody lowers brain Aβ in mice after single systemic dose. Mechanistic foundation of the Brain Shuttle delivery class.

From Yichao Yu et al. 2011, Science Translational Medicine

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

source-reported model organism

Conditions

Mouse PK/PD; TfR-bispecific anti-BACE1 antibody. Affinity-engineered for transcytosis kinetics.

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required