Radionuclide Selection Influences Imaging Outcomes in Immuno-PET with a Brain-Penetrating Anti-Amyloid-β Antibody. — Bispecific antibodies exploiting receptor-mediated transcytosis offer a promising strategy to overcome limited blood-brain barrier permeability in Alzheimer disease immunotherapy and imaging....

Evidence span

Radionuclide Selection Influences Imaging Outcomes in Immuno-PET with a Brain-Penetrating Anti-Amyloid-β Antibody. — Bispecific antibodies exploiting receptor-mediated transcytosis offer a promising strategy to overcome limited blood-brain barrier permeability in Alzheimer disease immunotherapy and imaging....

From Lopes van den Broek S et al. 2026, Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

source-reported model organism

Conditions

Brain; Animals; Mice; Zirconium; Iodine Radioisotopes — Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2026

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required