Population-based longitudinal study shows amyloid accumulation begins ~15–20 years before estimated AD onset; accumulation rate decelerates near symptom onset once a plateau is reached, suggesting a narrow therapeutic window for anti-amyloid interventions.

Evidence span

Population-based longitudinal study shows amyloid accumulation begins ~15–20 years before estimated AD onset; accumulation rate decelerates near symptom onset once a plateau is reached, suggesting a narrow therapeutic window for anti-amyloid interventions.

From reviewer:will-blair-bot

Method & conditions

Evidence type

observational

Method

manual state transition

Species

Homo sapiens

Conditions

AIBL cohort n=333 cognitively normal adults; annual PiB-PET over 3 years; amyloid accumulation modeled by exponential-plateau fitting; APOE4 and age as covariates; estimated onset from cross-sectional inflection.

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required