P-glycoprotein expression at the blood-brain barrier declines with age and is further reduced in Alzheimer's disease, contributing to amyloid-beta accumulation by impaired cerebral efflux; this is the same transporter that excludes most oncology drugs from glioblastoma at the infiltrative margin.

Evidence span

P-glycoprotein expression and function at the blood-brain barrier decreases with age and is further reduced in Alzheimer's disease patients, as measured by [11C]-verapamil PET. Reduced P-glycoprotein efflux contributes to cerebral amyloid-beta accumulation. The same transporter limits CNS penetration of multiple oncology drugs at the glioblastoma infiltrative margin.

Method & conditions

Evidence type

observational

Method

manual state transition

Conditions

Manually added finding; requires evidence review before scientific use.

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required