High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.

Evidence span

High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.

From Yu YJ et al. 2011, Sci Transl Med

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

source-reported model organism

Conditions

24 hours after systemic dosing of anti-TfR antibody variants

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required