Failed BACE1 inhibitor trials produce a measurable, directional confidence drift in the evidence graph for the amyloid cascade hypothesis. Predictions: Confidence weights on amyloid-cascade-supporting edges will decrease following the publication dates of the failed trials.; Targets downstream of BACE1 will show...

Evidence span

Failed BACE1 inhibitor trials produce a measurable, directional confidence drift in the evidence graph for the amyloid cascade hypothesis. Predictions: Confidence weights on amyloid-cascade-supporting edges will decrease following the publication dates of the failed trials.; Targets downstream of BACE1 will show...

Method & conditions

Evidence type

observational

Method

manual state transition

Conditions

Scope imported from broad Alzheimer's Therapeutics frontier; curator review required.

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required