Evaluation of 18F-flutemetamol amyloid PET image analysis parameters on the effect of verubecestat on brain amlyoid load in Alzheimer's disease. — PurposeThe BACE inhibitor verubecestat was previously found to reduce amyloid load as assessed by 18F-flutemetamol positron emission tomography (PET) composite cortical...

Evidence span

Evaluation of 18F-flutemetamol amyloid PET image analysis parameters on the effect of verubecestat on brain amlyoid load in Alzheimer's disease. — PurposeThe BACE inhibitor verubecestat was previously found to reduce amyloid load as assessed by 18F-flutemetamol positron emission tomography (PET) composite cortical...

From Sur C et al. 2022, Molecular imaging and biology

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

Homo sapiens

Conditions

Brain; Humans; Alzheimer Disease; Amyloidosis; Aniline Compounds — Molecular imaging and biology 2022

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required