Claudin-5 and occludin expression is reduced in cerebral microvasculature of early Alzheimer's disease post-mortem brain, paralleling the tight-junction breakdown observed in glioblastoma peritumoral vessels and consistent with a shared mechanism of BBB compromise across these otherwise unrelated diseases.

Evidence span

Cerebral microvasculature in early Alzheimer's disease post-mortem brain shows reduced expression of tight-junction proteins claudin-5 and occludin. Loss of these tight-junction components is consistent with a shared mechanism of blood-brain barrier compromise observed in other CNS pathologies including peritumoral glioma vasculature.

Method & conditions

Evidence type

observational

Method

manual state transition

Conditions

Manually added finding; requires evidence review before scientific use.

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required