Anti-TfR/BACE1 bispecific antibodies cross BBB in cynomolgus monkeys; reduce CSF and brain-tissue Aβ in dose-dependent fashion correlated with brain antibody concentration. Translates Yu 2011 mouse PK/PD into NHP, supporting clinical Brain Shuttle development.

Evidence span

Anti-TfR/BACE1 bispecific antibodies cross BBB in cynomolgus monkeys; reduce CSF and brain-tissue Aβ in dose-dependent fashion correlated with brain antibody concentration. Translates Yu 2011 mouse PK/PD into NHP, supporting clinical Brain Shuttle development.

From Yang Yu et al. 2014, Science Translational Medicine

Method & conditions

Evidence type

experimental

Method

manual state transition; control details require source inspection

Species

source-reported model organism

Conditions

Cynomolgus monkey + human-TfR knock-in mouse. Brain-shuttle-format BACE1 bispecific. Primate PK/PD.

Replicated

not yet

Confidence basis

operator-supplied frontier prior; review required